Condensation properties of stress granules and processing bodies are compromised in myotonic dystrophy type 1
Gulyurtlu, S., Magon, M. S., Guest, P. N., Papavasiliou, P. P., Morrison, K., Prescott, A. & Sleeman, J. E., 2 Aug 2022, In: Disease Models & Mechanisms. 15, 7, dmm049294.
Research output: Contribution to journal › Article › peer-review
The ‘most expensive drug in the world’, how it works and the devastating disease it treats
Sleeman, J. E., 19 Jul 2021, The Conversation.
Research output: Contribution to specialist publication › Article
Neurochondrin interacts with the SMN protein suggesting a novel mechanism for Spinal Muscular Atrophy pathology
Thompson, L. W., Morrison, K. D., Shirran, S. L., Groen, E. J. N., Gillingwater, T. H., Botting, C. H. & Sleeman, J. E., 17 Apr 2018, In: Journal of Cell Science. 131, 8, 18 p., jcs211482.
Research output: Contribution to journal › Article › peer-review
The Cajal body and the nucleolus: “in a relationship” or “it's complicated”?
Trinkle-Mulcahy, L. & Sleeman, J. E., 2017, In: RNA Biology. 14, 6, p. 739-751
Research output: Contribution to journal › Review article › peer-review
Nuclear bodies: new insights into assembly/dynamics and disease relevance
Sleeman, J. E. & Trinkle-Mulcahy, L., Jun 2014, In: Current Opinion in Cell Biology. 28, p. 76-83 8 p.
Research output: Contribution to journal › Article › peer-review
Time-resolved quantitative proteomics implicates the core snRNP protein SmB together with SMN in neural trafficking
Prescott, A. R., Bales, A., James, J., Trinkle-Mulcahy, L. & Sleeman, J. E., 14 Feb 2014, In: Journal of Cell Science. 127, 4, p. 812-827 15 p.
Research output: Contribution to journal › Article › peer-review
Transcriptionally correlated subcellular dynamics of MBNL1 during lens development and their implication for the molecular pathology of myotonic dystrophy type 1
Coleman, S., Prescott, A. R. & Sleeman, J. E., 1 Mar 2014, In: Biochemical Journal. 458, 2, p. 267-280 13 p.
Research output: Contribution to journal › Article › peer-review
Small nuclear RNAs and mRNAs: linking RNA processing and transport to spinal muscular atrophy
Sleeman, J., Aug 2013, In: Biochemical Society Transactions. 41, 4, p. 871-875 5 p.
Research output: Contribution to journal › Article › peer-review
Changes in intranuclear mobility of mature snRNPs provide a mechanism for splicing defects in spinal muscular atrophy
Clelland, A. K., Bales, A. B. E. & Sleeman, J. E., 1 Jun 2012, In: Journal of Cell Science. 125, 11, p. 2626-2637 12 p.
Research output: Contribution to journal › Article › peer-review
The SMN protein is a key regulator of nuclear architecture in differentiating neuroblastoma cells
Clelland, A. K., Kinnear, N. P., Oram, L., Burza, J. & Sleeman, J. E., Nov 2009, In: Traffic. 10, 11, p. 1585-1598 14 p.
Research output: Contribution to journal › Article › peer-review
A regulatory role for CRM1 in multi-directional trafficking of splicing snRNPs in the mammalian nucleus
Sleeman, J. E., 1 May 2007, In: Journal of Cell Science. 120, 9, p. 1540-1550 11 p.
Research output: Contribution to journal › Article › peer-review
Alterations in nuclear architecture in differentiating neuroblastoma cells
Burza, JR., Akbar, T. & Sleeman, J. E., Oct 2006, In: Differentiation. 74, p. 468 468 p.
Research output: Contribution to journal › Article › peer-review
Molecular and functional characterisation of microsomal UDP-glucuronic acid uptake by members of the nucleotide sugar transporter (NST) family.
Kobayashi, T., Sleeman, J. E., Coughtrie, MWC. & Burchell, B., 1 Dec 2006, In: Biochemical Journal. 400, 2, p. 281-289 9 p.
Research output: Contribution to journal › Article › peer-review
FRET analyses of the U2AF complex localize the U2AF35/U2AF65 interaction in vivo and reveal a novel self-interaction of U2AF35.
Chusainow, J., Ajuh, PM., Trinkle-Mulcahy, L., Sleeman, J. E., Ellenberg, J. & Lamond, AI., Aug 2005, In: RNA. 11, 8, p. 1204-1214
Research output: Contribution to journal › Article › peer-review
Dynamics of the mammalian nucleus: can microscopic movements help us to understand our genes?
Sleeman, J. E., 15 Dec 2004, In: Philosophical Transactions of the Royal Society. A, Mathematical, Physical and Engineering Sciences . 362, 1825, p. 2775-2793 19 p.
Research output: Contribution to journal › Article › peer-review
Cajal body proteins SMN and coilin show differential dynamic behaviour in vivo
Sleeman, J. E., Trinkle-Mulcahy, L., Prescott, AR., Ogg, SC. & Lamond, AI., 15 May 2003, In: Journal of Cell Science. 116, 10, p. 2039-2050 12 p.
Research output: Contribution to journal › Article › peer-review
Nuclear substructure and dynamics.
Sleeman, J. E. & Lamond, AI., 28 Oct 2003, In: Current Biology. 13, 21, p. R825-8 4 p.
Research output: Contribution to journal › Article › peer-review
Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs
Carnegie, GK., Sleeman, J. E., Morrice, N., Hastie, CJ., Peggie, MW., Philp, A., Lamond, AI. & Cohen, PT., 15 May 2003, In: Journal of Cell Science. 116, 10, p. 1905-13 9 p.
Research output: Contribution to journal › Article › peer-review
Time-lapse imaging reveals dynamic relocalization of PP1 throughout the mammalian cell cycle
Trinkle-Mulcahy, L., Andrews, PD., Wickramasinghe, S., Sleeman, J. E., Prescott, AR., Lam, YW., Lyon, CE., Swedlow, JR. & Lamond, AI., 2003, In: Molecular Biology of the Cell. 14, p. 861 861 p.
Research output: Contribution to journal › Article › peer-review
Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle.
Trinkle-Mulcahy, L., Andrews, PD., Wickramasinghe, S., Sleeman, J. E., Prescott, AR., Lam, Y., Lyon, CE., Swedlow, JR. & Lamond, AI., Jan 2003, In: Molecular Biology of the Cell. 14, 1, p. 107-17 11 p.
Research output: Contribution to journal › Article › peer-review
A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing.
Ajuh, PM., Sleeman, J. E., Chusainow, J. & Lamond, AI., 9 Nov 2001, In: Journal of Biological Chemistry. 276, 45, p. 42370-81 12 p.
Research output: Contribution to journal › Article › peer-review
Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells.
Trinkle-Mulcahy, L., Sleeman, J. E. & Lamond, AI., Dec 2001, In: Journal of Cell Science. 114, 23, p. 4219-4228 10 p.
Research output: Contribution to journal › Article › peer-review
snRNP protein expression enhances the formation of Cajal bodies containing p80-coilin and SMN
Sleeman, J. E., Ajuh, P. & Lamond, AI., Dec 2001, In: Journal of Cell Science. 114, 24, p. 4407-4419 13 p.
Research output: Contribution to journal › Article › peer-review
Newly assembled snRNPs associate with coiled bodies before speckles, suggesting a nuclear snRNP maturation pathway
Sleeman, J. E. & Lamond, AI., 7 Oct 1999, In: Current Biology. 9, 19, p. 1065-74 10 p.
Research output: Contribution to journal › Article › peer-review
Nuclear organization of pre-mRNA splicing factors.
Sleeman, J. E. & Lamond, AI., Jun 1999, In: Current Opinion in Cell Biology. 11, 3, p. 372-7 6 p.
Research output: Contribution to journal › Article › peer-review
Dynamic interactions between splicing snRNPs, coiled bodies and nucleoli revealed using snRNP protein fusions to the green fluorescent protein.
Sleeman, J. E., Lyon, CE., Platani, M., Kreivi, JP. & Lamond, AI., 15 Sept 1998, In: Experimental Cell Research. 243, 2, p. 290-304 15 p.
Research output: Contribution to journal › Article › peer-review
Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.
Neubauer, G., King, A., Rappsilber, J., Calvio, C., Watson, M., Ajuh, P., Sleeman, J. E., Lamond, A. & Mann, M., Sept 1998, In: Nature Genetics. 20, 1, p. 46-50 5 p.
Research output: Contribution to journal › Article › peer-review
Inhibition of Protein Dephosphorylation Results in the Accumulation of Splicing snRNPs and Coiled Bodies within the Nucleolus
Lyon, CE., Bohmann, K., Sleeman, J. E. & Lamond, AI., 10 Jan 1997, In: Experimental Cell Research. 230, 1, p. 84-93 10 p.
Research output: Contribution to journal › Article › peer-review
Trans-splicing in mammalian cells as revealed by gene trap insertions into ribosomal RNA genes
Sleeman, J. E., Moss, JE., Rosen, B. & Skarnes, WC., Nov 1995, In: Molecular Biology of the Cell. 6, p. 1134 1134 p.
Research output: Contribution to journal › Article › peer-review
Tumorigenicity associated ithe chromosome 11P15 alterations in SV40-transformed human kidney cells.
Poirier, V., Tyler, SJ., Sleeman, J. E., Diffin, F., Maitland, NJ. & Brown, KW., Sept 1995, In: International Journal of Oncology. 7, 3, p. 623-630 8 p.
Research output: Contribution to journal › Article › peer-review